The answer to the question on the previous blog, briefly is that rectal drug absorption takes place via both the portal and the systemic circulation (50/50 about). Only the portion that goes into the portal one will be subject a first pass loss (via liver metabolism, not of course acid destruction in stomach). So rectal absorption indeed produces a higher plasma concentration. Nice to have had so many good answers, in principle!
Oh, and to the person who asked whether there was a burp at the end of the preceding Xtra video: yes, indeed there was! Inserted via one of the sound options of the program - Do try the program and send your creations!
HB
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