A patient is maintained on an oral drug, given 4-hourly, but develops some adverse effects too frequently during periods of peak plasma concentrations. Measurements show that his plasma concentration fluctuates between 120 and 60 microgram/L.
The physician decides he would rather place him on a continuous infusion.
What maintenance dose rate would you suggest then?
Parameters for the drug are:
Bioavailability 25%
Volume of distribution: 2.4 L/kg
Pt. Weight: 80 Kg
Plasma Half-life: 4 hours
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