This dosing problem we will come back to after having discussed dosing issues in general - it follows from the previous blog on appropriate pain management in a pain crisis.
Say that the time to maximum effect for morphine is 8 min (I hope I remember correctly...) and that you needed to double the dose (as per the recommendations in the reference in the preceding blog) successively, thus giving 2+4+8+16 mg to have the patient pain free. Now, what would be the maintenance dose for this patient? How often would you have to repeat your administration, and how much would you give each time? For that you need some parameters. Which one or which ones?
Lets assume the following, and you then pick:
Volume of distribution: 82 L
Half-life: 4 hours (if you needed to (do you) you can calculate from this the clearance or the rate constant of elimination, of course).
1,2,3 go!
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