Let's see whether you understand
inverse antagonists etc:
- I you combine an agonist with a competitive antagonist you willA) never obtain a maximal responseB) get a negative response like with an inverse agonist alone.C) eventually will obtain a maximal effect when increasing the agonist concentration.D) get no or only a very small effect.
- If you combine an antagonist with an inverse agonist you willA) get a positive response instead of a negative one as you would in the absence of the inverse agonist.B) get no response when increasing the antagonist concentration.C) will get an increased negative effect.D) will form a black hole.
- If you combine a partial agonist with an inverse agonist you will getA) a maximal effect.B) a negative effect if you keep increasing the inverse agonist concentration.C) a negative effect if you keep increasing the partial agonist concentration.D) will precipitate a Big Bang.
Goods luck: I want to see responses
by each of you in the comment section!
Here's my attempt. Perhaps this is a good way for me to get over my fear of doing practice questions...
ReplyDelete1. C (b/c agonist + competetive antagonist aka competetive inhibitor fight for spots. If one increases [agonist] it will beat out the comp antagonist for spots)
2. B (b/c antagonist inhibits effects of the inverse agonist so if [antagonist] is increased, the inverse agonist will be inhibited more and more)
3. B (b/c partial agonist increases effect in the positive, inverse agonist increases effect in the negative, so increasing [inverse agonist] would increase the negative effect.
#1 - I think that even with an increase in the agonist, the antagonist will still reduce the effects of the agonist, so you will (A) never obtain a maximal response.
ReplyDelete#2 - I agree with Natalie, so (B).
#3 - B, almost 100% sure.
Courtney, I was teetering between A and C for #1. haha. At least I know one of us is correct since the other answers were definitely not correct :)
ReplyDelete1) A . . . because wouldn't the Antagonist competitively inhibit the receptor site therefore not allowing maximal binding of Agonist
ReplyDelete2) B I agree with the others
3) B
Answers are
ReplyDeleteC
B
B
Congrats.
Case 1: It is all a matter of mass action dynamics: when you keep on increasing the agonist concentration, at a constant antagonist level, you will eventually displace all of the antagonist from the receptors, and then you have a maximal effect, as per the efficacy of the antagonist.
still trying to get the hang of these pharmacology questions...hopefully I get used to them eventually!
ReplyDelete