Well, I had hardly finished my lunch and there was an answer already from Dr. Katz:
"There is no concern for oxygen toxicity since patients essentially can drown in their own secretions. So, therefore adequate oxygentation/ventilation is absolutely critical for treatment along with reversal of the toxicity with atropine/2-pam. Obviously it should be titrated to clinical effect especially if administered over days, but no different than any other patient in a critical illness situation."
(He is talking about oxygen toxicity - and the question really was concerned with whether or not there is an effect of oxygen on the distribution of drug (translocation to CNS)? I would love to see the original text the lady in class commented about.....)
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